The calculator combines a calculator for eGFR-MDRD (1,2,3) and a calculator for kineticGFR (4).
The following variables significantly affect calculated outputs:
- Choice of GFR estimator affects GFR calculations. MDRD was used in reference to Chen et al. (4).
- According to the National Kidney Foundation, laboratories should now be using a creatinine method that has been standardized or tracable to isotope dilution mass spectrometry (IDMS). The way creatinine levels are calibrated affects the GFR estimating equation. (3)
- The creatinine measurement unit (μmol/L versus mg/dL) affects the GFR estimating equation. Creatinine levels in μmol/L are converted to mg/dL in our calculator by dividing them by 88.4. (5)
- The value maximal rise in plasma creatinine per day is ambiguous. See Chen et al. for a discussion of this topic. (4)
- A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. Ann Intern Med. 1999 Mar 16;130(6):461-70. PMID: 10075613 [PubMed - indexed for MEDLINE]
- Levey A, Greene T, Kusek J, Beck G, Group MS. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 2000;11:155A
- Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values. Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration. Clin Chem. 2007 Apr;53(4):766-72. Epub 2007 Mar 1. PMID: 17332152 [PubMed - indexed for MEDLINE]
- Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. Chen S. J Am Soc Nephrol. 2013 May;24(6):877-88. doi: 10.1681/ASN.2012070653. Epub 2013 May 23. PMID: 23704286 [PubMed - indexed for MEDLINE]
All information is provided for educational purposes only.
This information should not be used for the diagnosis or treatment of any health problem or disease.
THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER.
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